ORIGINAL ARTICLE
Year : 2018  |  Volume : 12  |  Issue : 1  |  Page : 4-11

Evaluation of the effectiveness of glutamine in different times of administration in patients undergoing cardiopulmonary bypass during elective cardiac surgeries: randomized controlled study


Department of Anesthesia and Surgical Intensive Care, Zagazig University, Zagazig City, Egypt

Correspondence Address:
Heba M Fathi
Anesthesia Department, Zagazig Universality Hospital, Zagazig City, 44519
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejca.ejca_4_16

Rights and Permissions

Background Although glutamine (GLN) is considered one of the pharmacological preconditioning proteins in cardiac surgeries, there is no consensus in literatures regarding the ideal time of administration. This randomized, double-blinded comparative study compared the effectiveness of GLN administration at two different time points in patients undergoing cardiopulmonary bypass. Patients and methods A total of 75 patients were randomly distributed into three equal groups: group 1 received GLN for 3 days preoperatively, group 2 received GLN at the day of surgery starting at the induction of anesthesia, whereas group 3, the control group, did not receive GLN. Primary outcome included troponin I and creatine kinase-MB measured at 30 min, 6 h, 24 h, and 48 h after cardiopulmonary bypass (CPB). Secondary outcome included postbypass heart rate, blood pressure, ejection fraction by transesophageal echocardiography, systemic vascular resistance, ventilation time, incidence of arrhythmia and inotrope use, ICU and hospital stay, and mortality rate. The data were analyzed using statistical package for the social sciences (SPSS version 17), including χ2-test for qualitative variables and analysis of variance test for quantitative variables. P value of less than 0.05 was considered statistically significant. Results There was a significant decrease in troponin I at 6, 24, and 48 h (P=0.03, 0.02, and 0.04, respectively), creatine kinase-MB at 24 and 48 h (P=0.04 and 0.04, respectively), incidence of inotrope usage (P=0.019), incidence of arrhythmias (P=0.02), and ICU stay (P=0.04), whereas significant increase in ejection fraction and blood pressure in GLN-treated groups (groups 1 and 2). The time of administration did not significantly affect the results between group 1 and group 2. Conclusion GLN enhances myocardial protection. The time of administration did not significantly affect the results, so administration at induction of anesthesia is well tolerated and feasible.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed272    
    Printed31    
    Emailed0    
    PDF Downloaded65    
    Comments [Add]    

Recommend this journal